Hereditary Cancer Testing
When is hereditary cancer testing used?
What are the benefits of hereditary cancer testing?
The 31 gene Comprehensive Hereditary Cancer Panel is the flagship panel for Rainbow Diagnostics. The full gene list for this panel and the other panel options are shown in table 1 below.
What do the results mean?
Cancer is uncontrolled cell growth in an area of the body. When uncontrolled cell growth happens, it can form a tumour. Cancerous tumours can spread to other tissues which can affect how the body functions. Cancer is caused by variants in genes which normally control the growth and replication of cells. For more information please see Cancer Research UK.
Please refer to our hereditary cancer testing information on this website.
Yes. The test is available to all adults over the age of 18 regardless of any known health conditions and family history. Many people get tested when they have been diagnosed with cancer to find out if they have an inherited susceptibility gene which could have resulted in the cancer developing. This information can then be used to inform other family members.
Rainbow Diagnostics offer a range of testing kits to study genes associated with the most common hereditary cancers ranging from a comprehensive multi-cancer testing kit to targeted kits for breast, ovarian, colorectal, prostate, melanoma and pancreatic cancer.
The genes covered in each hereditary cancer testing kit are included in the table 1. All genes have been expertly curated and have known clinical associations with increased cancer risk.
The genes selected in the Rainbow Diagnostics hereditary cancer testing kits have been expertly chosen using scientific and medical literature and have been developed in accordance with national testing guidelines. All genetic variants reported will be clinically actionable and allow for informed decisions regarding risk management programmes.
Yes the BRCA 1 185delAG (c.68_69delAG), BRCA1 5382insC (c.5266dupC), and BRCA2 6174delT (c.5946delT) gene mutations can be detected by the Comprehensive Hereditary cancer panel, the hereditary breast cancer panel, the hereditary breast and gynaecological cancer panel (and the hereditary prostate cancer panel and the hereditary pancreatic cancer panel).
Next Generation Sequencing (NGS) is a large-scale, high-throughput technology that allows the order of nucleotide bases within a genome to be studied. NGS alongside bioinformatic analysis is widely used in both the medical healthcare industry as well as within clinical research to investigate different health conditions including cancer.
The team of HCPC registered clinical scientists at Rainbow Diagnostics will interpret your test results in accordance to well recognised best practice guidelines and provide you with a thorough report of your results.
Your results will be interpreted by our team of expert clinical scientists and the results will be returned securely either to yourself or to your healthcare provider dependent on your healthcare providers preferred method of return. All results are treated as fully confidential, and we will not share any personal details or test results with any third parties without your consent. Your result may become part of your record with your healthcare provider.
After completion of the testing process, the sample will be stored. Please refer to the consent information for further information regarding storage of DNA and data.
Please contact the laboratory via firstname.lastname@example.org to request a repeat tube or for any further questions regarding sampling.